Prazitel Plus+

Prazitel Plus+ Tablets for dogs & Puppies

For the control of tapeworms, roundworms, hookworms and whipworms in dogs and puppies.

Description
Prazitel Plus+ contains 50 mg Praziquantel, 150 mg Febantel, 144 mg Pyrantel Embonate.

It kills tapeworms, hookworms, whipworms and roundworms in dogs.

Uses
For the control of the following gastrointestinal tapeworms and roundworms of dogs and puppies:
Ascarids: Toxocara canis, Toxascaris leonina (adult and late immature forms).
Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults).
Whipworms: Trichuris vulpis (adults).
Tapeworms: Echinococcus species, Taenia species, Dipylidium caninum (adult and immature forms).

Dosage
For oral administration only.
The recommended dose rates are: 1 Prazitel Plus tablet per 10kg (22lbs) bodyweight. (15mg/kg bodyweight febantel, 14.4mg/kg pyrantel and 5 mg/kg praziquantel.)

The tablets can be given directly to the dog or disguised in food.

The recommended dose rates are: 15mg/kg bodyweight febantel, 14.4mg/kg pyrantel and 5 mg/kg praziquantel. This is equivalent to 1 Prazitel Plus tablet per 10kg (22lbs) bodyweight. The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment.

Puppies should be treated at 2 weeks of age and every 2 weeks until 12 weeks of age. Thereafter, they should be treated at 3 month intervals. It is advisable to treat the bitch at the same time as the puppies. For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every two weeks until weaning. For routine worm control, adult dogs should be treated every 3 months. For routine treatment a single dose is recommended. In the event of heavy roundworm infestation, a repeat dose should be given after 14 days.

Special precautions for use in animals Any part used tablet should be discarded. Consult a veterinary surgeon before treating pregnant animals for roundworms. Do not exceed the stated dose when treating pregnant bitches.

Contra-indications, warnings, etc:

Do not use simultaneously with piperazine compounds. Special warnings for each target species As a precautionary measure to prevent the establishment of Echinococcus multilocularis in Ireland and the UK, it is recommended that all dogs entering the country be treated with praziquantel.

Fleas serve as intermediate hosts for one common type of tapeworm Dipylidium caninum. Tapeworm infestation is certain to reoccur unless control of intermediate hosts such as fleas, mice, etc. is undertaken. Special precautions for use in animals Any part used tablet should be discarded. Consult a veterinary surgeon before treating pregnant animals for roundworms. Do not exceed the stated dose when treating pregnant bitches. Overdose (symptoms, emergency procedures, antidotes), if necessary The combination of praziquantel, pyrantel embonate and febantel is well tolerated in dogs. In safety studies, doses of 5 times the recommended dose or greater gave rise to occasional vomiting.

Special precautions to be taken by the person administering the veterinary medicinal product to animals. In the interest of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dogs food, should wash their hands afterwards.

Pharmacodynamic properties This product contains anthelmintics active against gastrointestinal roundworms and tapeworms. The product contains three active substances, as follows:

1. Febantel, a probenzimidazole 2. Pyrantel embonate (pamoate), a tetrahydropyrimidine derivative 3. Praziquantel, a partially hydrogenated pyrazinoisoquinoline derivative

In this fixed combination, pyrantel and febantel act against all relevant nematodes (ascarids, hookworms and whipworms) in dogs. In particular, the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis.

This combination shows synergistic activity in the case of hookworms and febantel is effective against T.vulpis. The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular Taenia spp., Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against all adult and immature forms of these parasites.

Praziquantel is very rapidly absorbed through the parasites surface and distributed throughout the parasite. Both in vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite integument, resulting in the contraction and paralysis of the parasites.

There is an almost instantaneous titanic contraction of the parasite musculature and a rapid vacuolization of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium. Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis of the nematodes and thereby allow removal from the gastrointestinal system by peristalsis. Within the mammalian system, febantel undergoes ring closure, forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption of structures vital to the normal functioning of the helminth. Glucose uptake in particular is affected, leading to a depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.

Perorally administered praziquantel is absorbed almost completely from the intestinal tract. Peroral administration is a safe and effective administration route and, under normal conditions, the parenteral administration has no advantages. The substance is metabolised very fast and excreted within 24 hours to more than 95% of the administered dosage. Only traces of non-metabolised praziquantel are excreted. The pamoate salt of pyrantel has low aqueous solubility, an attribute that reduces absorption and potentially increases pyrantel availability in the lumen of the intestine and thus increasing efficacy against nematodes of the gastrointestinal tract. Following absorption, pyrantel pamoate is quickly and almost completely broken down into a number of anthelmintically inactive metabolites. In most species studied, febantel is absorbed relatively rapidly and metabolised to a number of metabolites including fenbendazole and oxfendazole, which have anthelmintic activity.